Stenotrophomonas maltophilia healthcare-associated infections: identification of two main pathogenic genetic backgrounds.
Identifieur interne : 000377 ( Main/Exploration ); précédent : 000376; suivant : 000378Stenotrophomonas maltophilia healthcare-associated infections: identification of two main pathogenic genetic backgrounds.
Auteurs : C. Corlouer [France] ; B. Lamy [France] ; M. Desroches [France] ; J. Ramos-Vivas [Espagne] ; E. Mehiri-Zghal [Tunisie] ; O. Lemenand [France] ; J-M Delarbre [France] ; J-W Decousser [France]Source :
- The Journal of hospital infection [ 1532-2939 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Femelle (MeSH), Génotype (MeSH), Humains (MeSH), Infection croisée (microbiologie), Infection croisée (épidémiologie), Infections bactériennes à Gram négatif (microbiologie), Infections bactériennes à Gram négatif (épidémiologie), Jeune adulte (MeSH), Mâle (MeSH), Phénotype (MeSH), Stenotrophomonas maltophilia (classification), Stenotrophomonas maltophilia (génétique), Stenotrophomonas maltophilia (isolement et purification), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Typage par séquençage multilocus (MeSH).
- MESH :
- génétique : Stenotrophomonas maltophilia.
- isolement et purification : Stenotrophomonas maltophilia.
- microbiologie : Infection croisée, Infections bactériennes à Gram négatif.
- épidémiologie : Infection croisée, Infections bactériennes à Gram négatif.
- classification : Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Femelle, Génotype, Humains, Jeune adulte, Mâle, Phénotype, Stenotrophomonas maltophilia, Sujet âgé, Sujet âgé de 80 ans ou plus, Typage par séquençage multilocus.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Child (MeSH), Child, Preschool (MeSH), Cross Infection (epidemiology), Cross Infection (microbiology), Female (MeSH), Genotype (MeSH), Gram-Negative Bacterial Infections (epidemiology), Gram-Negative Bacterial Infections (microbiology), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Multilocus Sequence Typing (MeSH), Phenotype (MeSH), Stenotrophomonas maltophilia (classification), Stenotrophomonas maltophilia (genetics), Stenotrophomonas maltophilia (isolation & purification), Young Adult (MeSH).
- MESH :
- classification : Stenotrophomonas maltophilia.
- epidemiology : Cross Infection, Gram-Negative Bacterial Infections.
- genetics : Stenotrophomonas maltophilia.
- isolation & purification : Stenotrophomonas maltophilia.
- microbiology : Cross Infection, Gram-Negative Bacterial Infections.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Genotype, Humans, Male, Middle Aged, Multilocus Sequence Typing, Phenotype, Young Adult.
Abstract
BACKGROUND
Stenotrophomonas maltophilia is an opportunistic multi-drug-resistant bacterium responsible for healthcare-associated infections. Strategies for in-hospital infection control and management of carriers and environmental reservoirs remain controversial.
AIM
To determine the population structure of S. maltophilia strains in hospitalized infected patients and to identify putative highly pathogenic subpopulations that require upgraded infection control measures.
METHODS
Eighty-three diverse human strains of various clinical origins from 18 geographically distant hospitals were characterized phenotypically and genotypically using a multi-locus sequence typing (MLST) approach.
FINDINGS
Neither a predominant nor emerging sequence type (ST) was identified. Among the 80 typeable strains, only 29% corresponded to described STs, especially ST5 (N=6) and ST4/26/31 (N=2). The ST distribution and the phylogenic tree based on the concatenated MLST genes did not account for geographical, clinical origin or antimicrobial susceptibility clustering. A phylogenic tree that included 173 ST profiles from the MLST database and the 80 typeable strains confirmed the high genetic diversity of S. maltophilia, the previously reported genogroup organization and the predominance of genogroup 6, as it represented 41% (33/80) of the strains. Unexpectedly, genogroup 2 was the second most prevalent genogroup and included 16% (13/80) of the strains. These genogroups represented 57% (20/35) of the strains in respiratory patients and 75% (9/12) of the strains in patients with cystic fibrosis.
CONCLUSION
Beyond MLST, the over-representation of some genogroups among strains responsible for healthcare-associated infections was confirmed. Genogrouping affiliation is recommended to implement infection control measures selectively for the most pathogenic strains isolated from patient or environmental reservoirs.
DOI: 10.1016/j.jhin.2017.02.003
PubMed: 28318778
Affiliations:
- Espagne, France, Tunisie
- Alsace (région administrative), Gouvernorat de Tunis, Grand Est, Pays de la Loire, Provence-Alpes-Côte d'Azur, Île-de-France
- Créteil, Mulhouse, Nice, Saint-Nazaire, Tunis
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000438
- to stream PubMed, to step Curation: 000437
- to stream PubMed, to step Checkpoint: 000401
- to stream Main, to step Merge: 000377
- to stream Main, to step Curation: 000377
Le document en format XML
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Corlouer</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Bacteriology, Department of Microbiology, University Hospital Henri Mondor, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Bacteriology, Department of Microbiology, University Hospital Henri Mondor, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Lamy, B" sort="Lamy, B" uniqKey="Lamy B" first="B" last="Lamy">B. Lamy</name><affiliation wicri:level="3"><nlm:affiliation>Department of Bacteriology, Archet 2 Hospital, Nice Academic Hospital, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Bacteriology, Archet 2 Hospital, Nice Academic Hospital, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Desroches, M" sort="Desroches, M" uniqKey="Desroches M" first="M" last="Desroches">M. Desroches</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Bacteriology, Department of Microbiology, University Hospital Henri Mondor, Créteil, France; University Paris East Créteil, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Bacteriology, Department of Microbiology, University Hospital Henri Mondor, Créteil, France; University Paris East Créteil, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Ramos Vivas, J" sort="Ramos Vivas, J" uniqKey="Ramos Vivas J" first="J" last="Ramos-Vivas">J. Ramos-Vivas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Marqués de Valdecilla University Hospital and IDIVAL Research Institute, Santander, Cantabria, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Microbiology, Marqués de Valdecilla University Hospital and IDIVAL Research Institute, Santander, Cantabria</wicri:regionArea><wicri:noRegion>Cantabria</wicri:noRegion></affiliation></author><author><name sortKey="Mehiri Zghal, E" sort="Mehiri Zghal, E" uniqKey="Mehiri Zghal E" first="E" last="Mehiri-Zghal">E. Mehiri-Zghal</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Bacteriology, Abderahman MAMI Pneumo-Phthisiology Hospital, Tunis, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Bacteriology, Abderahman MAMI Pneumo-Phthisiology Hospital, Tunis</wicri:regionArea><placeName><settlement type="city">Tunis</settlement><region nuts="2">Gouvernorat de Tunis</region></placeName></affiliation></author><author><name sortKey="Lemenand, O" sort="Lemenand, O" uniqKey="Lemenand O" first="O" last="Lemenand">O. Lemenand</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Bacteriology, Saint Nazaire Hospital, Saint Nazaire, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Bacteriology, Saint Nazaire Hospital, Saint Nazaire</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Saint-Nazaire</settlement></placeName></affiliation></author><author><name sortKey="Delarbre, J M" sort="Delarbre, J M" uniqKey="Delarbre J" first="J-M" last="Delarbre">J-M Delarbre</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Bacteriology, Emile Muller Hospital, Mulhouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Bacteriology, Emile Muller Hospital, Mulhouse</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Mulhouse</settlement></placeName></affiliation></author><author><name sortKey="Decousser, J W" sort="Decousser, J W" uniqKey="Decousser J" first="J-W" last="Decousser">J-W Decousser</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Bacteriology, Department of Microbiology, University Hospital Henri Mondor, Créteil, France; University Paris East Créteil, Créteil, France. Electronic address: jean-winoc.decousser@hmn.aphp.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Bacteriology, Department of Microbiology, University Hospital Henri Mondor, Créteil, France; University Paris East Créteil, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author></analytic><series><title level="j">The Journal of hospital infection</title><idno type="eISSN">1532-2939</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Cross Infection (epidemiology)</term><term>Cross Infection (microbiology)</term><term>Female (MeSH)</term><term>Genotype (MeSH)</term><term>Gram-Negative Bacterial Infections (epidemiology)</term><term>Gram-Negative Bacterial Infections (microbiology)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Multilocus Sequence Typing (MeSH)</term><term>Phenotype (MeSH)</term><term>Stenotrophomonas maltophilia (classification)</term><term>Stenotrophomonas maltophilia (genetics)</term><term>Stenotrophomonas maltophilia (isolation & purification)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Femelle (MeSH)</term><term>Génotype (MeSH)</term><term>Humains (MeSH)</term><term>Infection croisée (microbiologie)</term><term>Infection croisée (épidémiologie)</term><term>Infections bactériennes à Gram négatif (microbiologie)</term><term>Infections bactériennes à Gram négatif (épidémiologie)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Phénotype (MeSH)</term><term>Stenotrophomonas maltophilia (classification)</term><term>Stenotrophomonas maltophilia (génétique)</term><term>Stenotrophomonas maltophilia (isolement et purification)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Typage par séquençage multilocus (MeSH)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Stenotrophomonas maltophilia</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cross Infection</term><term>Gram-Negative Bacterial Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Stenotrophomonas maltophilia</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Stenotrophomonas maltophilia</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Stenotrophomonas maltophilia</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Stenotrophomonas maltophilia</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infection croisée</term><term>Infections bactériennes à Gram négatif</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Cross Infection</term><term>Gram-Negative Bacterial Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infection croisée</term><term>Infections bactériennes à Gram négatif</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multilocus Sequence Typing</term><term>Phenotype</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Phénotype</term><term>Stenotrophomonas maltophilia</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Typage par séquençage multilocus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Stenotrophomonas maltophilia is an opportunistic multi-drug-resistant bacterium responsible for healthcare-associated infections. Strategies for in-hospital infection control and management of carriers and environmental reservoirs remain controversial.</p></div><div type="abstract" xml:lang="en"><p><b>AIM</b></p><p>To determine the population structure of S. maltophilia strains in hospitalized infected patients and to identify putative highly pathogenic subpopulations that require upgraded infection control measures.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Eighty-three diverse human strains of various clinical origins from 18 geographically distant hospitals were characterized phenotypically and genotypically using a multi-locus sequence typing (MLST) approach.</p></div><div type="abstract" xml:lang="en"><p><b>FINDINGS</b></p><p>Neither a predominant nor emerging sequence type (ST) was identified. Among the 80 typeable strains, only 29% corresponded to described STs, especially ST5 (N=6) and ST4/26/31 (N=2). The ST distribution and the phylogenic tree based on the concatenated MLST genes did not account for geographical, clinical origin or antimicrobial susceptibility clustering. A phylogenic tree that included 173 ST profiles from the MLST database and the 80 typeable strains confirmed the high genetic diversity of S. maltophilia, the previously reported genogroup organization and the predominance of genogroup 6, as it represented 41% (33/80) of the strains. Unexpectedly, genogroup 2 was the second most prevalent genogroup and included 16% (13/80) of the strains. These genogroups represented 57% (20/35) of the strains in respiratory patients and 75% (9/12) of the strains in patients with cystic fibrosis.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Beyond MLST, the over-representation of some genogroups among strains responsible for healthcare-associated infections was confirmed. Genogrouping affiliation is recommended to implement infection control measures selectively for the most pathogenic strains isolated from patient or environmental reservoirs.</p></div></front></TEI><affiliations><list><country><li>Espagne</li><li>France</li><li>Tunisie</li></country><region><li>Alsace (région administrative)</li><li>Gouvernorat de Tunis</li><li>Grand Est</li><li>Pays de la Loire</li><li>Provence-Alpes-Côte d'Azur</li><li>Île-de-France</li></region><settlement><li>Créteil</li><li>Mulhouse</li><li>Nice</li><li>Saint-Nazaire</li><li>Tunis</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Corlouer, C" sort="Corlouer, C" uniqKey="Corlouer C" first="C" last="Corlouer">C. Corlouer</name></region><name sortKey="Decousser, J W" sort="Decousser, J W" uniqKey="Decousser J" first="J-W" last="Decousser">J-W Decousser</name><name sortKey="Delarbre, J M" sort="Delarbre, J M" uniqKey="Delarbre J" first="J-M" last="Delarbre">J-M Delarbre</name><name sortKey="Desroches, M" sort="Desroches, M" uniqKey="Desroches M" first="M" last="Desroches">M. Desroches</name><name sortKey="Lamy, B" sort="Lamy, B" uniqKey="Lamy B" first="B" last="Lamy">B. Lamy</name><name sortKey="Lemenand, O" sort="Lemenand, O" uniqKey="Lemenand O" first="O" last="Lemenand">O. Lemenand</name></country><country name="Espagne"><noRegion><name sortKey="Ramos Vivas, J" sort="Ramos Vivas, J" uniqKey="Ramos Vivas J" first="J" last="Ramos-Vivas">J. Ramos-Vivas</name></noRegion></country><country name="Tunisie"><region name="Gouvernorat de Tunis"><name sortKey="Mehiri Zghal, E" sort="Mehiri Zghal, E" uniqKey="Mehiri Zghal E" first="E" last="Mehiri-Zghal">E. Mehiri-Zghal</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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